from version 2.1.0 VirtualBox has enabled by default a debugger called vboxdbg (DBGC) which runs on port 5000 of the host (your computer) and I have found no things on internet about how to disable it, and in reality there are also almost no details or informations about such "possibly interesting" service.
anyway the following bytes are enough for disabling it on the windows 2.1.0 host.
Code:
C:\Program Files\Sun\xVM VirtualBox\VBoxVMM.dll
offset original patched
-----------------------------
00084DF0 55 33
00084DF1 8B C0
00084DF2 EC C3